文章基本信息

标题：Combined Treatment With Radiotherapy and Immunotherapy for Isocitrate Dehydrogenase Mutant Brainstem Glioma in Adult: A Case Report
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作者：Takayuki Morimoto ; Ryosuke Matsuda ; Tsutomu Nakazawa 等
期刊名称：Brain Tumor Research and Treatment
印刷版ISSN：2288-2405
出版年度：2022
卷号：10
期号：2
页码：129-133
DOI：10.14791/btrt.2022.0009
语种：English
出版社：The Korean Brain Tumor Society and The Korean Society for Neuro-Oncology
摘要：Brainstem gliomas are not common in adults, and the treatment strategies and their outcomes are limited. Immunotherapy is emerging as a promising new modality for the treatment of these gliomas. Here, we report the first case of brainstem glioma treated with a combination of radiotherapy and autologous formalin-fixed tumor vaccine (AFTV). A 32-year-old man presented with left facial numbness and right hemiparesis, and was referred to our department. MRI and open biopsy indicated brainstem glioma, and he was specifically diagnosed with isocitrate dehydrogenase 1-mutant diffuse astrocytoma of WHO grade II. He was treated with stereotactic radiotherapy followed by AFTV three months later. MRI conducted at 42 months after the combination therapy showed a 91% decrease in tumor volume, and the regression was maintained for 5 years. Thus, combination treatment with radiotherapy and immunotherapy may prove to be a promising alternative for the treatment of brainstem glioma.
关键词：enGliomaAstrocytomaImmunotherapyRadiotherapyCancer vaccine