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标题：Effect of isoflavone supplementation on menopausal symptoms: a systematic review and meta-analysis of randomized controlled trials
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作者：Inhae Kang ; Chai Hong Rim ; Hee Sun Yang 等
期刊名称：Nutrition Research and Practice
印刷版ISSN：1976-1457
出版年度：2022
卷号：16
页码：S147-S159
DOI：10.4162/nrp.2022.16.S1.S147
语种：English
出版社：KoreaMed Synapse
摘要：BACKGROUND/OBJECTIVES Complementary and alternative medicines can be used to alleviate climacteric symptoms that significantly affect the quality of life of postmenopausal women. Isoflavones are the most common plant-based therapies for postmenopausal changes, but the results of previous studies have been controversial. MATERIALS/METHODS To investigate whether isoflavones would affect menopausal symptoms as well as ovarian hormones, we performed a systematic review and meta-analysis. The PubMed and EMBASE databases were used to perform the systematic search. Included studies were limited to randomized controlled trials (RCTs) assessing the impact of isoflavone supplementation on menopausal symptoms. RESULTS Eleven studies were included for the final quantitative assessment. Isoflavone intervention was varied between 49.3 and 135 mg of isoflavones per day for 12 wk–2 yrs. The meta-analysis showed that supplementation of isoflavones significantly increased the estradiol levels (standardized mean difference [SMD] = 0.615, P = 0.035) and Kupperman index (SMD = 3.121, P = 0.003) but had no significant effect on hot flashes, follicle-stimulating hormone, and luteinizing hormone. However, both estradiol and the Kupperman index showed significant heterogeneity among studies (I 2 = 94.7%, P < 0.001 and I 2 = 98.1%, P < 0.001, respectively). CONCLUSIONS Although the results showed a significant SMD in estradiol and the Kupperman index, the results should be interpreted with caution due to the high heterogeneity. Further validation with a larger RCT will be necessary. Overall, isoflavone supplementation has distinct effects on the climacteric symptoms and hormonal changes in postmenopausal women.
关键词：enIsoflavonespostmenopauseestradiolmeta-analysissystematic review