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标题：Antioxidant and antiplasmodial activities of Malus sikkimenmsis bioactives and their role in the suppression of LPS-induced neuroinflammation in glial cells
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作者：Shalini Dixit ; Shiv Vardan Singh ; Shilpa Mohanty 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2022
卷号：34
期号：4
页码：1-6
DOI：10.1016/j.jksus.2022.101919
语种：English
出版社：Elsevier
摘要：AbstractAs a part of our continued effort to isolate and identify the pharmacological properties of polyphenols fromMalus Sikkimensis, here in this work we have evaluated the neuroprotective effects of these polyphenols along with their antioxidant and antiplasmodial properties. The antioxidant potential of these bioactives was estimated using enzymatic and non-enzymatic methods of free radical generation, where phloretin (PT) displayed better antioxidant potential under both the conditions. Additionally, PT also exhibited significant antiplasmodial activity. Phloridzin (PZ) and phloretin (PT) were also studied for their effect on lipopolysaccharide (LPS) induced neuro-inflammation in rat (C6)glioma cells. Our results showed that pre-treatment of PZ and PT at 5 and 10 µg/ml concentrations significantly (p < 0.05) suppressed the release of pro-inflammatory cytokines (TNF-α and IL-6) in a dose dependent manner. Additionally, PT exhibited more potent anti-inflammatory activity than PZ without any cytotoxic effects, as estimated using MTT assay. These findings suggest that PT possessed promising anti-neuroinflammatory potential along with antioxidant and antiplasmodial activities, which may be enhanced further by structural modification and chemical derivatization.
关键词：KeywordsenMalus sikkimensisNeuroinflammationGlial cellsAntioxidantAntiplasmodialPhloretinPhloridzin