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标题：A physically active lifestyle is related to a lower level of skin autofluorescence in a large population with chronic-disease (LifeLines cohort)
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作者：Saskia Corine van de Zande ; Jeroen Klaas de Vries ; Inge van den Akker-Scheek 等
期刊名称：Journal of Sport and Health Science
印刷版ISSN：2095-2546
出版年度：2022
卷号：11
期号：2
页码：260-265
DOI：10.1016/j.jshs.2020.09.007
语种：English
出版社：Elsevier
摘要：Highlights • The study involved a large cohort of 63,425 participants with and without diabets mellitus, renal disease, and/or cardiovascular disease. • Increased skin autofluorescence is a marker of increased advanced glycation end-products and has already been shown to be associated with increased morbidity and mortality. • More hours of moderate to vigorous activity were associated with lower skin autofluorescence in the group with chronic disease. • More physical activity is associated with lower skin autofluorescence and could help to promote health and prolong longevity. Background Physical activity (PA) has substantial health benefits and is important in combatting chronic diseases, which have been associated with elevated levels of advanced glycation endproducts (AGEs). AGEs play a role in the aging process, and an association between PA and AGEs has been reported. We aimed to investigate the relationship between PA and AGE accumulation in a general population and in a population with chronic diseases. Methods This large cross-sectional population study used data from adult participants in the LifeLines project, with participant information drawn from the LifeLines database as well data from patients with diabetes mellitus or renal and/or cardiovascular diseases. Tissue AGE accumulation was assessed non-invasively by skin-autofluorescence (SAF) using an AGE reader (DiagnOptics Technologies BV, Groningen, the Netherlands). PA was assessed using the short questionnaire to assess health-enhancing physical activity (SQUASH). Multivariate linear regression analyses were adjusted for age, body mass index, sex, and smoking status. Results Data from 63,452 participants (general population n = 59,177, chronic disease n = 4275) were analyzed. The general population was significantly younger (43.58 ± 11.77 years, mean ± SD) and had significantly lower SAF (1.90 ± 0.42 arbitrary units (AU)) compared to the population with chronic disease (age: 55.51 ± 12.07 years; SAF: 2.27 ± 0.51 AU). In the group with chronic disease, more hours of moderate to vigorous physical activities per week were associated with lower SAF ( β = –0.002, 95% confidence interval (95%CI): –0.002 to –0.001). For the general population, there was no association between hours of moderate to vigorous activity and SAF ( β = 3.2  × 10 –5, 95%CI: 0.000–0.001, p = 0.742). However, there was an association in the general population between total hours of PA per week and SAF ( β = 4.2 × 10 –4, 95%CI: 0.000–0.001, p < 0.001), but this association was not found in the chronic disease population ( β = –3.2 × 10 –4, 95%CI: –0.001 to 0.000, p = 0.347). Conclusion Our study demonstrates that an inverse relationship exists between PA and AGE accumulation in the population with chronic disease. More hours of moderate to vigorous activity is associated with a significantly decreased SAF. More PA is associated with a lower SAF, even after adjusting for the established predictors (age, body mass index, smoking status, and sex). Our findings could help to promote health and prolong longevity. Graphical Abstract Image, graphical abstract
关键词：KeywordsenAdvanced glycation endproductsChronic disease populationGeneral populationPhysical activitySkin autofluorescence