文章基本信息

标题：New approach of using cortico-cortical evoked potential for functional brain evaluation (Review Article)
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作者：Hyunjin Jo ; Dongyeop Kim ; Jooyeon Song 等
期刊名称：Korean Journal of Clinical Neurophysiology
印刷版ISSN：1229-6414
出版年度：2021
卷号：23
期号：2
页码：69-81
DOI：10.14253/acn.2021.23.2.69
语种：English
出版社：KoreaMed Synapse
摘要：Cortico-cortical evoked potential (CCEP) mapping is a rapidly developing method for visualizing the brain network and estimating cortical excitability. The CCEP comprises the early N1 component the occurs at 10-30 ms poststimulation, indicating anatomic connectivity, and the late N2 component that appears at < 200 ms poststimulation, suggesting long-lasting effective connectivity. A later component at 200-1,000 ms poststimulation can also appear as a delayed response in some studied areas. Such delayed responses occur in areas with changed excitability, such as an epileptogenic zone. CCEP mapping has been used to examine the brain connections causally in functional systems such as the language, auditory, and visual systems as well as in anatomic regions including the frontoparietal neocortices and hippocampal limbic areas. Task-based CCEPs can be used to measure behavior. In addition to evaluations of the brain connectome, single-pulse electrical stimulation (SPES) can reflect cortical excitability, and so it could be used to predict a seizure onset zone. CCEP brain mapping and SPES investigations could be applied both extraoperatively and intraoperatively. These underused electrophysiologic tools in basic and clinical neuroscience might be powerful methods for providing insight into measures of brain connectivity and dynamics. Analyses of CCEPs might enable us to identify causal relationships between brain areas during cortical processing, and to develop a new paradigm of effective therapeutic neuromodulation in the future.
关键词：Evoked potentials;Connectome;Brain mapping;Electrophysiology