文章基本信息

标题：Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside TM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
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作者：Fabien Wauquier ; Line Boutin-Wittrant ; Line Pourtau 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2022
卷号：14
期号：7
DOI：10.3390/nu14071511
语种：English
出版社：MDPI Publishing
摘要：Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr’Inside TM) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron’s metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression.
关键词：enclinical trialdepressionserotoninBDNFdopamineSERTbrainmental healthcrocetinSH-SY5Y