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标题：Graphene quantum dots alleviate ROS-mediated gastric damage
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作者：Preety Choudhary ; Sushama Biswas ; Noufal Kandoth 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：4
页码：1-17
DOI：10.1016/j.isci.2022.104062
语种：English
出版社：Elsevier
摘要：SummaryThe gastrointestinal (GI) tract is one of the major sites for reactive oxygen species generation (ROS). Physiological ROS, lower than the threshold concentration, is beneficial for human physiology to preserve gut functional integrity. However, ROS generated in large quantities in presence of external stimuli overwhelms the cellular antioxidant defense mechanism and results in oxidative damage and associated physiological disorder. Graphene quantum dots (GQDs) are a class of carbon-based nanomaterials that have attracted tremendous attention not only for their tunable optical properties but also for their broad-spectrum antioxidant properties. In this report we have shown that GQDs are highly efficient in scavenging ROS and suppressing stress-induced gastric ulcers by targeting the MMP-9 pathway and reducing the inflammatory burden by suppressing excessive oxidative stress by inducing high caspase activity, overproduction of Bax, and downregulation of BCL2.Graphical abstractDisplay OmittedHighlights⋅The gastrointestinal tract is one of the major sites for ROS generation⋅Graphene quantum dots (GQDs) have broad-spectrum antioxidant properties⋅GQDs scavenge the ROS and suppress gastric ulcers by targeting the MMP-9 pathwayHuman metabolism; Molecular biology; Materials science; Nanomaterials