文章基本信息

标题：Vascularizing the brain in vitro
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作者：Abdellah Aazmi ; Hongzhao Zhou ; Weikang Lv 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：4
页码：1-31
DOI：10.1016/j.isci.2022.104110
语种：English
出版社：Elsevier
摘要：SummaryThe brain is arguably the most fascinating and complex organ in the human body. Recreating the brainin vitrois an ambition restricted by our limited understanding of its structure and interacting elements. One of these interacting parts, the brain microvasculature, is distinguished by a highly selective barrier known as the blood-brain barrier (BBB), limiting the transport of substances between the blood and the nervous system. Numerousin vitromodels have been used to mimic the BBB and constructed by implementing a variety of microfabrication and microfluidic techniques. However, currently available models still cannot accurately imitate thein vivocharacteristics of BBB. In this article, we review recent BBB models by analyzing each parameter affecting the accuracy of these models. Furthermore, we propose an investigation of the synergy between BBB models and neuronal tissue biofabrication, which results in more advanced models, including neurovascular unit microfluidic models and vascularized brain organoid-based models.Graphical abstractDisplay OmittedBiotechnology; Tissue Engineering; Materials science; Biomaterials