文章基本信息

标题：Rutin Attenuates Lipopolysaccharide-induced Nitric Oxide Production in Macrophage Cells
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作者：Seung-Jae Lee ; Seung Yuan Lee ; Hyun Joo Ha 等
期刊名称：Journal of Food and Nutrition Research
印刷版ISSN：2333-1119
电子版ISSN：2333-1240
出版年度：2015
卷号：3
期号：3
页码：202-205
DOI：10.12691/jfnr-3-3-12
语种：English
出版社：Science and Education Publishing
摘要：Rutin is the major polyphenol found in buckwheat and can downregulate inflammatory responses in macrophages. However, the underlying mechanism is unclear. Overproduction of nitric oxide (NO) by inducible nitric synthase (iNOS) is closely correlated with inflammation and the pathology of a variety of diseases. It has been reported that rutin inhibited various pro-inflammatory mediators, including cytokine signaling in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells, and suppressed the production of NO and the expression of cyclooxygenase-2 (COX-2) and iNOS protein in LPS-stimulated macrophages. These results suggest that rutin exerts anti-inflammatory effects by suppressing the expression of COX-2 and iNOS in RAW 264.7 macrophage cells. Therefore, rutin can be considered as a functional food for the prevention of various diseases.
关键词：anti-inflammation; buckwheat; macrophage cells; nitric oxide; rutin