文章基本信息

标题：Ethanol Extract of Polygonatumofficinale Rhizome Inhibits Odorant-Induced Camp and Calcium Levels in Non-Chemosensory 3T3-L1 Cells
本地全文：下载
作者：Yeo Cho Yoon ; Sung-Hee Kim ; Jin-Taek Hwang 等
期刊名称：Journal of Food and Nutrition Research
印刷版ISSN：2333-1119
电子版ISSN：2333-1240
出版年度：2014
卷号：2
期号：11
页码：776-780
DOI：10.12691/jfnr-2-11-3
语种：English
出版社：Science and Education Publishing
摘要：Polygonatum Officinalerhizome, a member of the liliaceae family, is commonly consumed as tea in Asia. It is also clinically used to treat obesity and fatigue in Korean traditional medicine. Although the anti-diabetic effect of POR has been described, little is known about its physiological role in the olfactory system. In this study, we investigated the effects of POR in 3T3-L1 cells expressing an odorant receptor. We have shown that the levels of cAMP and Ca²⁺ and the phosphorylation of Rap1A and CREB increased in response to an odorant, eugenol. POR significantly decreased the eugenol-induced increase in cAMP and Ca²⁺. Taken together, these data suggest that POR inhibits an odorant-induced signal transduction pathway.
关键词：cAMP; adenylyl cyclase; olfactory; polygonatumofficinale; 3T3-L1