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标题：Lifetime Assessment of Dietary Nucleotides Consumption in Sprague-Dawley Rats
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作者：Meihong Xu ; Rui Liang ; Qianying Guo 等
期刊名称：Journal of Food and Nutrition Research
印刷版ISSN：2333-1119
电子版ISSN：2333-1240
出版年度：2014
卷号：2
期号：11
页码：806-813
DOI：10.12691/jfnr-2-11-8
语种：English
出版社：Science and Education Publishing
摘要：To assess the long-term toxicity and carcinogenicity of dietary nucleotides (NTs), Sprague-Dawley rats were administered the NTs for life-through with the dose of 0, 0.01%, 0.04%, 0.16% and 0.64%. With the exception of several groups, the results showed no significant differences in weight gain, clinical symptoms data, blood indicators, and Non-neoplastic lesions frequencies. NTs have dramatically increased the food consumption of both sexes (P<0.05). Meanwhile, NTs decreased spontaneous tumor incidence of both sexes, notably the male rats (P<0.05). The occurrence of all malignant and mammary tumors in NTs-treated females was lower than those in controls (P<0.05). In comparison with the control group, the incidence of death from malignant and systemic tumors were obviously decreased in the NTs-treated groups (P<0.01). Moreover, our results showed that a higher percentage of rats in the NTs-treated groups died of non-neoplastic lesions compared with control. In conclusion, dietary nucleotides are not toxic or carcinogenic in rats up to 0.64% for all the life, and 0.64% was an unobservable eﬀect dose.
关键词：dietary nucleotides; safety; lifelong; Spontaneous Tumor Incidence; Sprague-Dawley rat