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标题：First case of Whipple’s disease successfully treated with tigecycline
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作者：Kalliopi Foteinogiannopoulou ; Ioannis Mouzas ; Maria Tzardi 等
期刊名称：Germs
印刷版ISSN：2248-2997
出版年度：2021
卷号：11
期号：1
页码：105-110
DOI：10.18683/germs.2021.1246
语种：English
出版社：European HIV/AIDS and Infectious Diseases Academy
摘要：Introduction Whipple’s disease is a rare chronic infectious disease caused by Tropheryma whipplei. The infection mainly affects the small intestine of middle-aged patients, approximately three times more often in males than in females causing malabsorption and excessive weight loss but other organs may be affected as well.Case report We describe a case of a 42-year-old woman with a history of chronic diarrhea and weight loss evolving for at least the last 6 years. The diagnosis of Whipple’s disease was confirmed by histopathological examination of duodenal biopsy samples with Periodic acid–Schiff positive macrophages and by polymerase chain reaction technique detecting the DNA of Tropheryma whipplei. The patient was commenced on several antimicrobials including beta-lactams and co-trimoxazole but she did not improve. Finally, after-long lasting i.v. tigecycline 100 mg BID she was commenced on p.o. doxycycline along with hydroxychloroquine 200 mg TID for one year and after by p.o. doxycycline alone.Discussion The intriguing thing with this case was not only the natural resistance to co-trimoxazole but that the infection was controlled empirically with long-lasting i.v. tigecycline since several failed attempts to discontinue i.v. treatment followed. This might be due to erratic absorption of oral drugs due to gut inflammation.Conclusions To our knowledge, this is the first case of Whipple’s disease successfully treated with long-lasting induction parenteral tigecycline followed by p.o. doxycycline along with hydroxychloroquine for one year and after by p.o. doxycycline alone.
关键词：Support vector machine;software defined network;machine learning;distributed Dos;detection