文章基本信息

标题：The role of microbiome in colorectal carcinogenesis and its clinical potential as a target for cancer treatment
本地全文：下载
作者：Sang Hoon Kim ; Yun Jeong Lim
期刊名称：Intestinal Research
印刷版ISSN：1598-9100
电子版ISSN：2288-1956
出版年度：2022
卷号：20
期号：1
页码：31-42
DOI：10.5217/ir.2021.00034
语种：English
出版社：Korean Association for the Study of Intestinal Diseases
摘要：The role of gut microbiome-intestinal immune complex in the development of colorectal cancer and its progression is well recognized. Accordingly, certain microbial strains tend to colonize or vanish in patients with colorectal cancer. Probiotics, prebiotics, and synbiotics are expected to exhibit both anti-tumor effects and chemopreventive effects during cancer treatment through mechanisms such as xenometabolism, immune interactions, and altered eco-community. Microbial modulation can also be safely used to prevent complications during peri-operational periods of colorectal surgery. A deeper understanding of the role of intestinal microbiota as a target for colorectal cancer treatment will lead the way to a better prognosis for colorectal cancer patients.