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标题：Genetics, leadership position, and well-being: An investigation with a large-scale GWAS
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作者：Zhaoli Song ; Wen-Dong Li ; Xuye Jin 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2022
卷号：119
期号：12
DOI：10.1073/pnas.2114271119
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Significance Our study presents the largest whole-genome investigation of leadership phenotypes to date. We identified genome-wide significant loci for leadership phenotypes, which are overlapped with top hits for bipolar disorder, schizophrenia, and intelligence. Our study demonstrated the polygenetic nature of leadership, the positive genetic correlations between leadership traits and a broad range of well-being indicators, and the unique association of leadership with well-being after accounting for genetic influences related to other socioeconomic status measures. Our findings offer insights into the biological underpinnings of leadership. Twin studies document leadership role occupancy (e.g., whether one holds formal supervisory or management positions) as a heritable trait. However, previous studies have been underpowered in identifying specific genes associated with this trait, which has limited our understanding of the genetic correlations between leadership and one’s well-being. We conducted a genome-wide association study (GWAS) on individuals’ leadership phenotypes that were derived from supervisory/managerial positions and demands among 248,640 individuals of European ancestry from the UK Biobank data. Among the nine genome-wide significant loci, the identified top regions are pinpointed to previously reported GWAS loci for bipolar disorder ( miR-2113/POUSF2 and LINC01239) and schizophrenia loci ( ZSWIM6). We found positive genetic correlations between leadership position and several positive well-being and health indicators, including high levels of subjective well-being, and low levels of anxiety and depression (| r g | > 0.2). Intriguingly, we observed positive genetic correlations between leadership position and some negative well-being indicators, including high levels of bipolar disorder and alcohol intake frequency. We also observed positive genetic correlations between leadership position and shortened longevity, cardiovascular diseases, and body mass index after partialing out the genetic variance attributed to either educational attainment or income. The positive genetic correlation between leadership and bipolar disorder seems potentially more pronounced for those holding senior leadership positions ( r g : 0.10 to 0.24), partially due to shared genetic variants with educational attainment. Our findings provide insights into the polygenic nature of leadership and shared genetic underpinnings between the leadership position and one’s health and well-being. We caution against simplistic interpretations of our findings as advocating genetic determinism.
关键词：enGWASleadershipwell-beinggeneticsmanagement