文章基本信息

标题：Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia
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作者：Antonio Pazienti ; Andrea Galluzzi ; Miguel Dasilva 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：3
页码：1-22
DOI：10.1016/j.isci.2022.103918
语种：English
出版社：Elsevier
摘要：SummaryIn the arousal process, the brain restores its integrative activity from the synchronized state of slow wave activity (SWA). The mechanisms underpinning this state transition remain, however, to be elucidated. Here we simultaneously probed neuronal assemblies throughout the whole cortex with micro-electrocorticographic recordings in mice. We investigated the progressive shaping of propagating SWA at different levels of isoflurane. We found a form of memory of the wavefront shapes at deep anesthesia, tightly alternating posterior-anterior-posterior patterns. At low isoflurane, metastable patterns propagated in more directions, reflecting an increased complexity. The wandering across these mesostates progressively increased its randomness, as predicted by simulations of a network of spiking neurons, and confirmed in our experimental data. The complexity increase is explained by the elevated excitability of local assemblies with no modifications of the network connectivity. These results shed new light on the functional reorganization of the cortical network as anesthesia fades out.Graphical abstractDisplay OmittedHighlights•Complexity of isoflurane-induced slow waves reliably determines anesthesia level•In deep anesthesia, the propagation strictly alternates between front-back-front patterns•In light anesthesia, there is a continuum of directions and faster propagation•Local excitability underpins the cortical reorganization in fading anesthesiaNeuroscience; Experimental models in systems biology