文章基本信息

标题：Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea
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作者：Philine Marchetta ; Philipp Eckert ; Robert Lukowski 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：3
页码：1-28
DOI：10.1016/j.isci.2022.103981
语种：English
出版社：Elsevier
摘要：SummaryThe key auditory signature that may associate peripheral hearing with central auditory cognitive defects remains elusive. Suggesting the involvement of stress receptors, we here deleted the mineralocorticoid and glucocorticoid receptors (MRandGR) using a CaMKIIα-based tamoxifen-inducible CreERT2/loxPapproach to generate mice with single or double deletion of central but not cochlear MR and GR. Hearing thresholds of MRGRCaMKIIαCreERT2conditional knockouts (cKO) were unchanged, whereas auditory nerve fiber (ANF) responses were larger and faster and auditory steady state responses were improved. Subsequent analysis of single MR or GR cKO revealed discrete roles for both, central MR and GR on cochlear functions. Limbic MR deletion reduced inner hair cell (IHC) ribbon numbers and ANF responses. In contrast, GR deletion shortened the latency and improved the synchronization to amplitude-modulated tones without affecting IHC ribbon numbers. These findings imply that stress hormone-dependent functions of central MR/GR contribute to “precognitive” sound processing in the cochlea.Graphical abstractDisplay OmittedHighlights•Top-down MR/GR signaling differentially contributes to cochlear sound processing•Limbic MR stimulates auditory nerve fiber discharge rates•Central GR deteriorates auditory nerve fiber synchronyMolecular neuroscience; Cellular neuroscience; Sensory neuroscience