文章基本信息

标题：Longevity interventions temporally scale healthspan in Caenorhabditis elegans
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作者：Cyril Statzer ; Peter Reichert ; Jürg Dual 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：3
页码：1-18
DOI：10.1016/j.isci.2022.103983
语种：English
出版社：Elsevier
摘要：SummaryHuman centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population. However, whether longevity is caused by a compression of the portion of life spent in a state of morbidity,i.e., “sickspan,” is highly debated even in isogenicCaenorhabditis elegans. Here, we developed a microfluidic device that employs acoustophoretic force fields to quantify the maximum muscle strength and dynamic power in agingC. elegans. Together with different biomarkers for healthspan, we found a stochastic onset of morbidity, starting with a decline in dynamic muscle power and structural integrity, culminating in frailty. Surprisingly, we did not observe a compression of sickspan in longevity mutants but instead observed a temporal scaling of healthspan. Given the conservation of these longevity interventions, this raises the question of whether the healthspan of mammalian longevity interventions is also temporally scaled.Graphical abstractDisplay OmittedHighlights•We developed a microfluidics device to assess healthspan ofC. elegans•Acoustophoretic force fields to quantify dynamic muscle power•Healthspan is neither extended nor compressed by longevity interventionsBiological sciences; Physiology; Biophysics