文章基本信息

标题：Circulating tumor cells: Towards mechanical phenotyping of metastasis
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作者：Marina Peralta ; Naël Osmani ; Jacky G. Goetz 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：3
页码：1-12
DOI：10.1016/j.isci.2022.103969
语种：English
出版社：Elsevier
摘要：SummaryDuring cancer progression, metastatic dissemination accounts for ∼90% of death in patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through body fluids, in particular the bloodstream, and several key steps remain elusive. Although the majority of CTCs travel as single cells, they can form clusters either with themselves (homoclusters) or with other circulating cells (heteroclusters) and thereby increase their metastatic potential. In addition, cancer cell mechanics and mechanical cues from the microenvironment are important factors during metastatic progression. Recent progress in intravital imaging technologies, biophysical methods, and microfluidic-based isolation of CTCs allow now to probe mechanics at single cell resolution while shedding light on key steps of the hematogenous metastatic cascade. In this review, we discuss the importance of CTC mechanics and their correlation with metastatic success and how such development could lead to the identification of therapeutically relevant targets.Graphical abstractDisplay OmittedMechanobiology; Biological sciences; Cancer; Biological sciences research methodologies