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标题：Comparison between short-term stress and long-term adaptive responses reveal common paths to molecular adaptation
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作者：Xiumin Chen ; Yanzhu Ji ; Yalin Cheng 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：3
页码：1-19
DOI：10.1016/j.isci.2022.103899
语种：English
出版社：Elsevier
摘要：SummaryThe phenotypic plasticity in responses to short-term stress can provide clues for understanding the adaptive fixation mechanism of genetic variation during long-term exposure to extreme environments. However, few studies have compared short-term stress responses with long-term evolutionary patterns; in particular, no interactions between the two processes have been evaluated in high-altitude environment. We performed RNA sequencing in embryo fibroblasts derived from great tits and mice to explore transcriptional responses after exposure to simulated high-altitude environmental stresses. Transcriptional changes of genes associated with metabolic pathways were identified in both bird and mice cells after short-term stress responses. Genomic comparisons among long-term highland tits and mammals and their lowland relatives revealed similar pathways (e.g., metabolic pathways) with that initiated under short-term stress transcriptional responsesin vitro. These findings highlight the indicative roles of short-term stress in the long-term adaptation, and adopt common paths to molecular adaptation in mouse and bird cells.Graphical abstractDisplay OmittedHighlights•Short-term stress and long-term adaptations share the common metabolic pathways•Phenotypic plasticity can promote adaptive evolution•Adopt common paths to molecular adaptation in mouse and bird cellsBiological sciences; Genetics; Genomics; Cell biology