文章基本信息

标题：Machine learning for artemisinin resistance in malaria treatment across in vivo-in vitro platforms
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作者：Hanrui Zhang ; Jiantao Guo ; Hongyang Li 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：3
页码：1-16
DOI：10.1016/j.isci.2022.103910
语种：English
出版社：Elsevier
摘要：SummaryDrug resistance has been rapidly evolving with regard to the first-line malaria treatment, artemisinin-based combination therapies. It has been an open question whether predictive models for this drug resistance status can be generalized acrossin vivo-in vitrotranscriptomic measurements. In this study, we present a model that predicts artemisinin treatment resistance developed with transcriptomic information ofPlasmodium falciparum. We demonstrated the robustness of this model acrossin vivoclearance rate andin vitroIC50 measurement and based on different microarray and data processing modalities. The validity of the algorithm is further supported by its first placement in the DREAM Malaria challenge. We identified transcription biomarkers to artemisinin treatment resistance that can predict artemisinin resistance and are conserved in their expression modules. This is a critical step in the research of malaria treatment, as it demonstrated the potential of a platform-robust, personalized model for artemisinin resistance using molecular biomarkers.Graphical abstractDisplay OmittedHighlights•Artemisinin resistance can be predicted from transcriptomes by machine learning•Our model can be transferred betweenin vivoandin vitroand different platforms•We identified top transcription biomarkers of artemisinin resistancePharmaceutical science; Microbiology parasite; Bioinformatics; Artificial intelligence