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标题：Antifungal potential of Colchicum luteum and determination of colchicine content using HPLC for application as a fungicide
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作者：Rauoof Ahmad Rather ; Haleema Bano ; Kahkashan Perveen 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2022
卷号：34
期号：3
页码：1-6
DOI：10.1016/j.jksus.2022.101876
语种：English
出版社：Elsevier
摘要：AbstractColchicum luteumL. is an economically important medicinal plant species of the North Western Himalaya.The corm extract of this plant is utilized in the treatment of many diseases. It is also used extensively in plant breeding program for the doubling of chromosomes. The antifungal activities of aqueous and ethanolic extracts of the corm of the medicinal plantColchicum luteumwere investigated in this study. These extracts were tested against the fungi,Colletotrichumsp. andFusarium oxysporum. The ethanolic extract of corm (100 mg mL−1) inhibitedColletotrichumsp. andF. oxysporumwith inhibition zones of 19.2 mm and 18.3 mm, respectively, whereas the aqueous extract of corm (100 mg mL−1) inhibitedColletotrichumsp. andF. oxysporumwith inhibition zones of 17.1 mm and 15.2 mm, respectively. Colchicine was isolated from several plant components (corms, seeds, leaves, and flowers) and its concentration was determined using high-performance liquid chromatography (HPLC). The corm had the highest percentage of colchicine (0.191% ± 0.036) of all the plant parts examined, followed by the seeds (0.103% ± 0.021). As a result, it can be said that the corms and seeds ofC. luteumcould serve as a natural source of colchicine for the pharmaceutical industry.
关键词：KeywordsenColchicum luteumAntifungalKirby-Bauer testColchicineSustainable environmentHPLC