文章基本信息

标题：Hospitalization and mortality trends among patients with confirmed COVID-19 in the United States, April through August 2020
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作者：Jennifer L. Nguyen ; Michael Benigno ; Deepa Malhotra 等
期刊名称：Journal of Public Health Research
印刷版ISSN：2279-9028
电子版ISSN：2279-9036
出版年度：2022
卷号：11
期号：1
DOI：10.4081/jphr.2021.2244
语种：English
出版社：PAGEPress Publications
摘要：Background: The United States has experienced high COVID- 19 case counts, hospitalizations, and death rates. This retrospective analysis reports changing trends in the demographics and clinical outcomes of hospitalized US COVID-19 patients between April and August 2020. Design and methods: The Premier Healthcare Database Special Release was used to examine patient demographics of hospitalized COVID-19 patients from all US Census Bureau divisions. Demographics included age, sex, race, and ethnicity. Clinical outcomes included in-hospital mortality, intensive care unit (ICU) admission, and receipt of invasive mechanical ventilation. Results: Overall, 146,491 hospitalized COVID-19 patients were included (mean [SD] age, 61.0 [18.4] years; 51.7% male; 29.6% White non-Hispanic). Monthly total hospitalizations decreased from 44,854 in April to 18,533 in August; ICU admissions increased from 19.8% to 23.6%, and ventilator use and inpatient mortality decreased from 18.6% to 14.5% and 21.0% to 11.4%, respectively. Inpatient mortality was highest in the Middle Atlantic division (20.3%), followed by the New England (19.0%), East North Central (14.2%), and Mountain (13.7%) divisions. Black non-Hispanic patients were overrepresented among hospitalizations (19.0%); this group comprises 12.2% of the US population. Patients aged <65 years made up 53% of hospitalizations and had lower inpatient mortality than those aged ≥65 years. Conclusions: Hospitalizations, ventilator use, and mortality decreased, while ICU admission rates increased from April to August 2020. Older individuals and Black non-Hispanics were found to be at elevated risk of severe outcomes. These trends could inform ongoing patient care and US public health policies to limit the further spread of SARS-CoV-2. Significance for public health The impact of the COVID-19 pandemic on public health in the United States has been significant. Due to the ever-evolving nature of the pandemic, healthcare workers and public health experts require a thorough understanding of the clinical outcomes of hospitalized COVID-19 patients. This study found that despite decreases in overall mortality rates as the pandemic continues, certain demographic groups, including the elderly and Black non-Hispanics remain disproportionately affected. Such information could inform ongoing care of COVID-19 patients, as well as shape public health policies to address health disparities to limit the ongoing spread of SARS-CoV-2.
关键词：Key wordsenClinical outcomesCOVID-19hospitalizationmortalitytrends