文章基本信息

标题：Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving Rodents
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作者：Joseph T. Marmerstein ; Grant A. McCallum ; Dominique M. Durand 等
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2022
卷号：12
期号：2
DOI：10.3390/bios12020114
语种：English
出版社：MDPI Publishing
摘要：The vagus nerve is the largest autonomic nerve and a major target of stimulation therapies for a wide variety of chronic diseases. However, chronic recording from the vagus nerve has been limited, leading to significant gaps in our understanding of vagus nerve function and therapeutic mechanisms. In this study, we use a carbon nanotube yarn (CNTY) biosensor to chronically record from the vagus nerves of freely moving rats for over 40 continuous hours. Vagal activity was analyzed using a variety of techniques, such as spike sorting, spike-firing rates, and interspike intervals. Many spike-cluster-firing rates were found to correlate with food intake, and the neural-firing rates were used to classify eating and other behaviors. To our knowledge, this is the first chronic recording and decoding of activity in the vagus nerve of freely moving animals enabled by the axon-like properties of the CNTY biosensor in both size and flexibility and provides an important step forward in our ability to understand spontaneous vagus-nerve function.
关键词：envagus nerveintraneuraldecodingintrafascicularrecordingcarbon nanotube