文章基本信息

标题：Evidence of Anxiety, Depression and Learning Impairments following Prenatal Hypertension
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作者：Kedra Wallace ; Teylor Bowles ; Ashley Griffin 等
期刊名称：Behavioral Sciences
电子版ISSN：2076-328X
出版年度：2022
卷号：12
期号：2
DOI：10.3390/bs12020053
语种：English
出版社：MDPI Publishing
摘要：Background: Hypertensive disorders of pregnancy, such as Preeclampsia (PreE) and HELLP (hemolysis, elevated liver enzyme, low platelet) syndrome, affects approximately 5–10% of pregnancies and increases the risk of women developing disorders, such as anxiety or depression, in the postpartum period. Using preclinical rodent models, we set out to determine whether rats with a history of PreE or HELLP had evidence of anxiety, depression or cognitive impairment and whether immune suppression during pregnancy prevented these changes in mood and/or cognition. Methods: Timed-pregnant rats were infused with sFlt-1 and/or sEng to induce PreE or HELLP beginning on gestational day 12. After delivery, a battery of validated behavioral assays was used to assess post-partum depression, anxiety and learning. Results: There was no negative effect on maternal pup interaction due to PreE or HELLP; however, hypertensive dams spent more time immobile in the forced swim test ( p < 0.0001). Hypertensive dams also spent less time in the open area of the open field ( p = 0.001). There were no significant changes in recognition memory ( p = 0.08); however, spatial learning was impaired in hypertensive dams ( p = 0.003). Immobility time in the forced swim test was positively correlated with increased circulating S100B ( p = 0.04), while increased time spent in the outer zones of the open field was negatively correlated with BDNF levels ( p < 0.0001). Conclusion: The results from this study suggest that hypertensive pregnancy disorders are associated with depression, anxiety and learning impairments in the post-partum period.
关键词：enanti-angiogenicmemoryHELLP syndromeplacental ischemiapregnancypost-partumpreeclampsia