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标题：Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study
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作者：Paula Jhoana Escobedo-Aedo ; Ana Forjan-González ; Adela Sánchez-Escribano Martínez 等
期刊名称：Behavioral Sciences
电子版ISSN：2076-328X
出版年度：2022
卷号：12
期号：2
DOI：10.3390/bs12020028
语种：English
出版社：MDPI Publishing
摘要：Background: Recovery has become a priority in schizophrenia spectrum disorders (SSDs). This study aimed to investigate predictors of objective—general functioning and disability—and subjective—quality of life (QoL)—measures of functional outcomes in SSD. Methods: Sample: n = 77 SSD outpatients (age 18–64, IQ > 70) participating in a randomised controlled trial. Baseline data were used to build three multivariable linear regression models on: (i) general functioning—General Assessment of Functioning (GAF); (ii) disability—the World Health Organization Disability Assessment Schedule (WHODAS-2.0); and (iii) QoL—Satisfaction Life Domains Scale (SLDS). Results: Young age and being employed (R 2 change = 0.211; p = 0.001), late adolescence premorbid adjustment (R 2 change = 0.049; p = 0.0050), negative symptoms and disorganization (R 2 change = 0.087; p = 0.025) and Theory of Mind (R 2 change = 0.066, p = 0.053) predicted general functioning. Previous suicidal behaviour (R 2 change = 0.068; p = 0.023) and negative and depressive symptoms (R 2 change = 0.167; p = 0.001) were linked with disability. Previous suicidal behaviour (R 2 change = 0.070, p = 0.026), depressive symptoms (R 2 change = 0.157; p < 0.001) and illness recognition (R 2 change = 0.046, p = 0.044) predicted QoL. Conclusions: Negative, disorganization and depressive symptoms, older age, unemployment, poor premorbid adjustment, previous suicide attempts and illness awareness appear to underlie a poor global functional outcome in SSD. Achieving recovery in SSD appears to require both symptomatic remission (e.g., through antipsychotics) and measures to improve mastery and relieve low mood.
关键词：enmetacognitionschizophrenia spectrum disordersdisabilityfunctioningquality of life