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标题：Production, characterization and growth inhibitory potential of metabolites produced by Pseudomonas and Bacillus species
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作者：Oghenerobor B. Akpor ; Mmesoma A. Okonkwo ; Tolulope A. Ogunnusi 等
期刊名称：Scientific African
印刷版ISSN：2468-2276
出版年度：2022
卷号：15
页码：1-10
DOI：10.1016/j.sciaf.2021.e01085
语种：English
出版社：Elsevier
摘要：AbstractA variety of metabolites obtained from microbes are indicated to have anti-inflammatory, anticancer and antibiotics activities. This study was therefore aimed at assessing the antibacterial potentials of metabolites produced by four bacterial species against selected pathogens. The study was carried out under batch conditions. A 24 h old culture of each bacteria species was inoculated into 200 mL medium in 250 mL capacity conical flasks and incubated. The metabolites showed antimicrobial activity against the selected typed and clinical isolates. In presence of the respective crude metabolites, growth ofSalmonella typhiandKlebsiella pneumoniaewere observed to be inhibited during the period of incubation, except for setup that contained metabolites produced by theBacillus cereus.The metabolite combinations fromP. aeruginosa and P. fuscoginae, P. aeruginosa and B. subtilisand fromP. aeruginosa and B. cereuswere observed to inhibit most of the isolates. Structural characterization of the metabolites detected the presence of peptide-like moiety, as well as aliphatic hydrocarbons. The antimicrobial potential shown by the metabolites is a promising indication for further studies to be carried out with respect to possible safe use of the purified metabolites as potential antimicrobials in humans and animals.
关键词：KeywordsAntimicrobialBioactive compoundsMicrobial growthInhibitory concentrationSecondary metabolitesMicrobial inhibition