文章基本信息

标题：Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity
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作者：Yvonne Rericha ; Dunping Cao ; Lisa Truong 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：2
页码：1-15
DOI：10.1016/j.isci.2022.103789
语种：English
出版社：Elsevier
摘要：SummaryPer- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in environmental and biological samples and cause adverse health effects. Studies have predominately focused on long-chain PFAS, with far fewer addressing short-chain alternatives. This study leveraged embryonic zebrafish to investigate developmental toxicity of a short-chain series: perfluorobutane sulfonate (PFBS), perfluoropentanoic acid (PFPeA), perfluorobutane sulfonamide (FBSA), and 4:2 fluorotelomer sulfonic acid (4:2 FTS). Following static exposures at 8 h postfertilization (hpf) to each chemical (1–100 μM), morphological and behavioral endpoints were assessed at 24 and 120 hpf. Only FBSA induced abnormal morphology, while exposure to all chemicals caused aberrant larval behavior. RNA sequencing at 48 hpf following 47 μM exposures revealed only FBSA significantly disrupted normal gene expression. Measured tissue concentrations were FBSA > PFBS > 4:2 FTS > PFPeA. This study demonstrates functional head groups impact bioactivity and bioconcentration.Graphical abstractDisplay OmittedHighlights•Perfluorobutane sulfonamide (FBSA) was the most developmentally toxic and bioaccumulative in a homologous series•FBSA, PFBS, PFPeA, and 4:2 FTS induced abnormal larval behavior•FBSA exposure induced transcriptional changes that preceded morphological effectsChemistry; Surface chemistry; Toxicology; Developmental biology