文章基本信息

标题：Freestanding nanomaterials for subcellular neuronal interfaces
本地全文：下载
作者：Elaine Liang ; Jiuyun Shi ; Bozhi Tian 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：1
页码：1-13
DOI：10.1016/j.isci.2021.103534
语种：English
出版社：Elsevier
摘要：SummaryCurrent technological advances in neural probing and modulation have enabled an extraordinary glimpse into the intricacies of the nervous system. Particularly, nanomaterials are proving to be an incredibly versatile platform for neurological applications owing to their biocompatibility, tunability, highly specific targeting and sensing, and long-term chemical stability. Among the most desirable nanomaterials for neuroengineering, freestanding nanomaterials are minimally invasive and remotely controlled. This review outlines the most recent developments of freestanding nanomaterials that operate on the neuronal interface. First, the different nanomaterials and their mechanisms for modulating neurons are explored to provide a basis for how freestanding nanomaterials operate. Then, the three main applications of subcellular neuronal engineering—modulating neuronal behavior, exploring fundamental neuronal mechanism, and recording neuronal signal—are highlighted with specific examples of current advancements. Finally, we conclude with our perspective on future nanomaterial designs and applications.Graphical abstractDisplay OmittedBiotechnology; Materials science; Nanomaterials; Neuroscience