文章基本信息

标题：Gut Ruminococcaceae levels at baseline correlate with risk of antibiotic-associated diarrhea
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作者：Xiaoqiong Gu ; Jean X.Y. Sim ; Wei Lin Lee 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：1
页码：1-16
DOI：10.1016/j.isci.2021.103644
语种：English
出版社：Elsevier
摘要：SummaryAntibiotic-associated diarrhea (AAD) affects a significant proportion of patients receiving antibiotics. We sought to understand if differences in the gut microbiome would influence the development of AAD. We administered a 3-day course of amoxicillin-clavulanate to 30 healthy adult volunteers, and analyzed their stool microbiome, using 16S rRNA gene sequencing, at baseline and up to 4 weeks post antibiotic administration. Lower levels of gut Ruminococcaceae were significantly and consistently observed from baseline until day 7 in participants who developed AAD. Overall, participants who developed AAD experienced a greater decrease in microbial diversity. The probability of AAD could be predicted based on qPCR-derived levels ofFaecalibacterium prausnitziiat baseline. Our findings suggest that a lack of gut Ruminococcaceae influences development of AAD. Quantification ofF. prausnitziiin stool prior to antibiotic administration may help identify patients at risk of AAD, and aid clinicians in devising individualized treatment regimens to minimize such adverse effects.Graphical abstractDisplay OmittedHighlights•Antibiotic-associated diarrhea (AAD) affects a significant proportion of patients•13/30 healthy volunteers who received oral amoxicillin-clavulanate developed AAD•Individuals who developed AAD had lower levels of gut Ruminococcaceae at baseline•Baseline levels ofFaecalibacterium prausnitziiwere predictive of risk of AADHealth sciences; Pathophysiology; Microbiome