文章基本信息

标题：Tracking the amino acid changes of spike proteins across diverse host species of severe acute respiratory syndrome coronavirus 2
本地全文：下载
作者：Srinivasulu Yerukala Sathipati ; Sanjay K. Shukla ; Shinn-Ying Ho 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2022
卷号：25
期号：1
页码：1-20
DOI：10.1016/j.isci.2021.103560
语种：English
出版社：Elsevier
摘要：SummaryKnowledge of the host-specific properties of the spike protein is of crucial importance to understand the adaptability of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to infect multiple species and alter transmissibility, particularly in humans. Here, we propose a spike protein predictor SPIKES incorporating with an inheritable bi-objective combinatorial genetic algorithm to identify the biochemical properties of spike proteins and determine their specificity to human hosts. SPIKES identified 20 informative physicochemical properties of the spike protein, including information measures for alpha helix and relative mutability, and amino acid and dipeptide compositions, which have shown compositional difference at the amino acid sequence level between human and diverse animal coronaviruses. We suggest that alterations of these amino acids between human and animal coronaviruses may provide insights into the development and transmission of SARS-CoV-2 in human and other species and support the discovery of targeted antiviral therapies.Graphical abstractDisplay OmittedHighlights•Differences exist in the amino acids within the S protein of diverse host species CoVs•We developed SPIKES to identify informative properties of S protein•SARS-CoV-2 variants have amino acid changes that alter infection and transmission•The SPIKES identified changes in S protein properties from animal to human host CoVsAssociation analysis; Bioinformatics; Virology