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标题：Multifactorial antioxidant potential of novel compounds isolated from Zanthoxylum armatum fruits along with cytotoxicity studies on HepG2 cell lines
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作者：Ateeque Ahmad ; Ateeque Ahmad ; Sudeep Tandon 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2022
卷号：34
期号：2
页码：1-8
DOI：10.1016/j.jksus.2021.101792
语种：English
出版社：Elsevier
摘要：Graphical abstractDisplay OmittedAbstractObjectiveOxidative stress causes multidirectional damage including different types of cancers in our body by affecting the normal physiological functions of the cells and tissues. The objective is to study the cytotoxic and antioxidant potential of natural compounds isolated from fruits ofZ. armatumDC.MethodsThis study was designed to investigate the chemical nature as well as biological effects of natural compounds. The isolated compounds were tested for antioxidant effect in various ways e.g. DPPH free radical inhibition, ferric reducing effect, superoxide dismutase, and catalase evaluation. The cytotoxic effect of isolated compounds was evaluated using HepG2 cancer cells.ResultsChemical investigations on the fruits ofZ. armatumDC, led to the isolation of two new compounds characterized as (cis)-2, 8-dimethyl-non-5-en-8-ol-2-olyl benzoate (1), (cis)-2, 10-dimethyl-undec-7-en-10-ol-2-olyl benzoate (2) along with five known compounds such asn-dodecanyl linoleniate (3),n-octacos-10, 20-dienoic acid (4), (cis,cis)-dotriacont-6, 12-dienoic acid (5), lignoceric acid (6), and (cis,cis)-dotriacont-6, 8-dienoic acid (7).Compound1shows potent activity against HepG2 cancer cells in comparison2and significantly affected the viability of cells till 48 hrs. The highest antioxidant potential among compounds and extracts with respect to DPPH free radical inhibition and the ferric reducing effect was shown by compound1followed by2and7with an EC50 value of 19.44, 20.44 and, 22.46 respectively.ConclusionsThe present study indicates that compound (1) showed a significant effect against HepG2 cancer cells as well as antioxidant potential through DPPH and FRAP methods. Compounds 2 and 7 also proved to be useful up to some extent for antioxidant potential.
关键词：Zanthoxylum armatum;R;utaceae;Fruits;N;ew compounds;Cytotoxic;Antioxidant