文章基本信息

标题：Synthesis of silver nanoparticle (Ag NPs) using phytochemical rich medicinal plant Lonicera japonica for improve the cytotoxicity effect in cancer cells
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作者：Govindan Nadar Rajivgandhi ; Govindan Nadar Rajivgandhi ; Gnanasekaran Chackaravarthi 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2022
卷号：34
期号：2
页码：1-7
DOI：10.1016/j.jksus.2021.101798
语种：English
出版社：Elsevier
摘要：AbstractInitially, the excellent anti-oxidant property of the Ag NPs was synthesized from Chinese medicinal plant ofLonicera japonica,and their spectroscopic evidences were confirmed by UV-spectrometer. The morphology, size and shape of the synthesized Ag NPs were effectively identified by scanning electron microscope and transmission electron microscope. Both the spectroscopic results were more evident, which UV-spectrometer peak was exhibited at 456 nm, scanning electron microscope and transmission electron microscope results were also clearly shown ball like spherical shape. The potential anti-cancer effect of the Ag NPs was revealed, the selected Chinese plantLonicera japonicawas influenced the A549 lung cancer cells through excessive ROS production. The IC50concentration of 75 µg/mL was shown decreased viability in Ag NPs treated A549 lung cancer cells of MTT assay. Consecutively, the MTT assay result was proved by irregular shape and damaged morphology in A549 lung cancer cells by images of phase contrast microscope. Finally, the result was also clearly stated that the synthesized Ag NPs was very effective against A549 human lung cancer cells and it use for future drug discovery for inhibiting the lung cancer.
关键词：Medicinal plant;Silver nanoparticle;Anti-oxidant activity;Cancer cells;Cell viability;Morphological damage;Phase contrast microscope