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标题：In vivo antioxidant efficacy and therapeutic potential of Artemisia brevifolia leaves extract against CCl 4-induced reproductive damages in male albino rats
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作者：Muhammad Umar Ijaz ; Mudassar Iqbal ; Muhammad Adnan Iqbal 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2022
卷号：34
期号：2
页码：1-6
DOI：10.1016/j.jksus.2021.101816
语种：English
出版社：Elsevier
摘要：AbstractThe current study was aimed to investigate the alleviative effect ofArtemisia brevifolia(A. brevifolia) plant extract against CCl4-induced testicular damage in male albino rats. Forty-eight male albino rats were categorized into eight equal experimental groups i.e., control, vehicle control, CCl4(1 ml/kg), CCl4 + silymarin, CCl4 + A. brevifolia(150 mg/kg), CCl4 + A. brevifolia(300 mg/kg),A. brevifolia(150 mg/kg) andA. brevifolia(300 mg/kg). After 56 days, blood and testicular samples were collected, and antioxidant enzyme activity, lipid peroxidation, hormonal concentration, daily sperm production (DSP), and histomorphometry were analyzed. The animals treated with theA. brevifoliaextract exhibited a significant (p < 0.05) increase in the catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), glutathione reductase (GR) activity, and significant (p < 0.05) decrease in thiobarbituric acid reactive substances (TBARS) level, potentially damaged by CCl4. Significant (p < 0.05) restoration in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone concentrations, and DSP was observed in theA. brevifoliatreated groups. Besides, CCl4significantly (p < 0.05) dysregulated the lipid profile by increasing cholesterol, LDL, and triglycerides, while reducing HDL. The histopathological analysis evinced that CCl4significantly (p < 0.05) damaged the testicular tissues. However,A. brevifoliatreatment considerably abated the detrimental effects of CCl4in rat testes. In conclusion, our results suggested the therapeutic role ofA. brevifoliain oxidative stress-related disorders of testes.
关键词：Artemisia brevifolia;Carbon tetrachloride;Oxidative stress;Testicular damage;Albino rat;Antioxidant enzymes