文章基本信息

标题：The Research Progress on Cocrystals of Flavonoids
本地全文：下载
作者：Yingfan Xia ; Renjie Xu ; Chengjun Jiang 等
期刊名称：Open Access Library Journal
印刷版ISSN：2333-9705
电子版ISSN：2333-9721
出版年度：2022
卷号：9
期号：1
页码：1-18
DOI：10.4236/oalib.1108320
语种：English
出版社：Scientific Research Pub
摘要：Flavonoids are an important class of natural organic compounds that widely exist in nature and have rich medicinal value. Cocrystal technology is an effective method to improve the solubility of insoluble flavonoids. The cocrystal formers and the hydroxyl groups in the flavonoid compound form a new crystal structure through hydrogen bonding, and the original lattice packing and molecular arrangement have changed. On the premise of not changing the active ingredients of the drug, the solubility of the drug is improved, thereby improving the drug absorption and increasing the bioavailability. This article reviews the research progress of drug cocrystals of flavonoids, and provides a reference for the application of flavonoids in medicine.
关键词：FlavonoidsCocrystal TechnologyTraditional Chinese MedicineHydrogen BondDrug AbsorptionBioavailability