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标题：Evaluation of an Ionic Calcium Fiber Supplement and Its Impact on Bone Health Preservation in a Dietary Calcium Deficiency Mice Model
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作者：Sara Elisa Herrera-Rodríguez ; Eristeo García-Márquez ; Eduardo Padilla-Camberos 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2022
卷号：14
期号：3
DOI：10.3390/nu14030422
语种：English
出版社：MDPI Publishing
摘要：Ionic calcium can help in the prevention of the process of osseous decalcification. This study aimed to evaluate the physicochemical properties and toxic effects of ionic calcium-fiber supplement ( ICa + ) and its impact on bone health preservation in mice C57/BL6 fed a calcium-deficient diet. Physicochemical properties include FTIR, apparent calcium solubility estimated by the calcium ratio obtained by ionization chromatography and atomic absorption. In vitro genotoxicity and cytotoxicity of the ICa + were assessed. Twenty-five 7-week-old C57/BL6 mice were fed calcium-free diet (CFD) or CFD plus CaCO 3 (1.33 mg Ca) or CFD plus ICa + (1.33–6.66 mg Ca) for six weeks. After that, bone mass and microstructure parameters were assessed. Histological staining was performed to determine calcium deposits. ICa + (100%) exhibited an apparent calcium solubility higher than CaCO 3 (12.3%). ICa + showed no cytotoxic and genotoxic in vitro activities. Histomorphometry analysis showed that the ICa + treated group displayed a higher trabecular number than the trabecular space. Also, the ratio BV/TV was increased compared with all treatments. Ionic calcium-fiber supplementation prevents bone deterioration compared to mice fed a calcium-deficient diet.
关键词：enionic calciumfiber supplementationosteoporosiscalcium-free diet