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标题：Edible bird’s nest extract downregulates epidermal apoptosis and helps reduce damage by ultraviolet radiation in skin of hairless mice
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作者：Shinya Masuda ; Yuko Makioka-Itaya ; Tetsuo Ijichi 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2022
卷号：70
期号：1
页码：33-36
DOI：10.3164/jcbn.21-54
语种：English
出版社：The Society for Free Radical Research Japan
摘要：The purpose of the present study was to examine whether daily intake of edible bird’s nest extract reduced ultraviolet-induced damage to skin. Twenty-one female HR-1/Hos mice were divided into control (C, n = 7), low-dose (2 mg/kg body weight/day of edible bird’s nest extract) (L, n = 7), and high-dose (20 mg/kg body weight/day of edible bird’s nest extract) (H, n = 7) groups. With their left back skin covered with aluminum sheet to prevent exposure, mice were radiated with either ultraviolet A (20 J/cm 2) or ultraviolet B (40 mJ/cm 2) in an alternate manner once daily for 10 weeks. They were gavaged either a solution of saline or edible bird’s nest extract every day. The moisture content of the ultraviolet-exposed right back skin was significantly higher in H than in C or L. Histochemical analysis showed that the number of apoptotic epidermal cells on the ultraviolet-exposed skin was significantly lower in L and H than in C. In H, the mRNA expression of superoxide dismutase 2 was significantly higher on ultraviolet-exposed skin than on unexposed skin. Our data suggested that edible bird’s nest extract enhanced superoxide dismutase 2 expression and downregulated apoptosis in their epidermis, which likely helped reduce skin damage.
关键词：enapoptosisedible bird’s nest extractskin damagesuperoxide dismutaseultraviolet