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标题：Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
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作者：José Jaime Martínez-Magaña ; Sandra Hernandez ; Ana Rosa Garcia 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2022
卷号：14
期号：2
DOI：10.3390/nu14020394
语种：English
出版社：MDPI Publishing
摘要：Alterations in eating behavior characterized eating disorders (ED). The genetic factors shared between ED diagnoses have been underexplored. The present study performed a genome-wide association study in individuals with disordered eating behaviors in the Mexican population, blood methylation quantitative trait loci (blood-meQTL), summary data-based Mendelian randomization (SMR) analysis, and in silico function prediction by different algorithms. The analysis included a total of 1803 individuals. We performed a genome-wide association study and blood-meQTL analysis by logistic and linear regression. In addition, we analyzed in silico functional variant prediction, phenome-wide, and multi-tissue expression quantitative trait loci. The genome-wide association study identified 44 single-nucleotide polymorphisms (SNP) associated at a nominal value and seven blood-meQTL at a genome-wide threshold. The SNPs show enrichment in genome-wide associations of the metabolic and immunologic domains. In the in silico analysis, the SNP rs10419198 ( p-value = 4.85 × 10 −5) located on an enhancer mark could change the expression of PRR12 in blood, adipocytes, and brain areas that regulate food intake. Additionally, we found an association of DNA methylation levels of SETBP1 ( p-value = 6.76 × 10 −4) and SEMG1 ( p-value = 5.73 × 10 −4) by SMR analysis. The present study supports the previous associations of genetic variation in the metabolic domain with ED.
关键词：enfeeding and eating disordergenome-wide association studymethylation quantitative trait loci