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标题：Age-Dependent Decline of NAD +—Universal Truth or Confounded Consensus?
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作者：Augusto Peluso ; Mads V. Damgaard ; Marcelo A. S. Mori 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2022
卷号：14
期号：1
DOI：10.3390/nu14010101
语种：English
出版社：MDPI Publishing
摘要：Nicotinamide adenine dinucleotide (NAD +) is an essential molecule involved in various metabolic reactions, acting as an electron donor in the electron transport chain and as a co-factor for NAD +-dependent enzymes. In the early 2000s, reports that NAD + declines with aging introduced the notion that NAD + metabolism is globally and progressively impaired with age. Since then, NAD + became an attractive target for potential pharmacological therapies aiming to increase NAD + levels to promote vitality and protect against age-related diseases. This review summarizes and discusses a collection of studies that report the levels of NAD + with aging in different species (i.e., yeast, C. elegans, rat, mouse, monkey, and human), to determine whether the notion that overall NAD + levels decrease with aging stands true. We find that, despite systematic claims of overall changes in NAD + levels with aging, the evidence to support such claims is very limited and often restricted to a single tissue or cell type. This is particularly true in humans, where the development of NAD + levels during aging is still poorly characterized. There is a need for much larger, preferably longitudinal, studies to assess how NAD + levels develop with aging in various tissues. This will strengthen our conclusions on NAD metabolism during aging and should provide a foundation for better pharmacological targeting of relevant tissues.
关键词：enNAD+agingyeastC. elegansmouseratmonkeyhuman