文章基本信息

标题：Drug Induced Liver Injury: Perspective of the Adverse Drug Reaction Reports to the Portuguese Pharmacovigilance System from 2010 to 2019
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作者：David Ricardo da Conceição Marçal Alves Nunes ; Michèle Claire Breton ; Cristina Sofia de Jesus Monteiro 等
期刊名称：Healthcare
电子版ISSN：2227-9032
出版年度：2021
卷号：9
期号：12
DOI：10.3390/healthcare9121630
语种：English
出版社：MDPI Publishing
摘要：Background: Drug induced liver injury (DILI) is an adverse drug reaction that causes liver damage in a predictable (dose-dependent) or an unpredictable (idiosyncratic) fashion. We performed an assessment of DILI in Portugal, by analyzing the reports, sent to the Portuguese Pharmacovigilance System (PPS). Methods: A search was performed on the PPS database, in a 10-year time frame, from 1 January 2010 to 31 December 2019. Results: There was not a prevalence of either sex in any age group. Most reports ( n = 1120, 55.0%) belonged to patients in the age group 19–64 years old. Hepatitis ( n = 626, 26.7%) was the most common adverse drug reaction in our study. Hepatotoxicity ( n = 362, 15.5%) and hepatitis ( n = 333, 14.2%) were more frequent in age group 19–64 years old. Cholestasis was more prevalent in adults independently of age. Hepatic fibrosis and encephalopathy were more common in the elderly. Most patients consumed between one and four suspected drugs ( n = 1867, 92%). Most patients in our study evolved to “cure” ( n = 796; 39%). Hepatotoxicity ( n = 23; 13.8%) and hepatitis ( n = 610; 25.9%) had a female predominancy while choluria ( n = 8; 4.8%) and splenomegaly ( n = 8; 4.8%) were of male predominance. Conclusions: DILI is rare but can be fatal. As such, an active search of DILI is necessary.
关键词：drug induced liver diseases; adverse drug reaction reporting systems; pharmacovigilance system; product surveillance; post-marketing