文章基本信息

标题：A selective Cu ^II complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells
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作者：Pedro Henrique Alves Machado ; Drielly Aparecida Paixão ; Ricardo Campos Lino 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
DOI：10.1038/s41598-021-03909-1
语种：English
出版社：Springer Nature
摘要：The thin line between efficacy and toxicity has challenged cancer therapy. As copper is an essential micronutrient and is important to tumor biology, Cu II complexes emerged as an alternative to chemotherapy; however, its biological properties need to be better understood. Thus, we report in vitro the antitumor effects of two Cu II complexes named [Cu(4-fh)(phen)(ClO 4) 2