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标题：Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles
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作者：Amirtham J.A. Ranjitsingh ; Amirtham J.A. Ranjitsingh ; Sandhanasamy Devanesan 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2022
卷号：34
期号：1
页码：1-7
DOI：10.1016/j.jksus.2021.101693
语种：English
出版社：Elsevier
摘要：AbstractObjectiveAlternative medicine plays an important role today in searching for therapeutics for cancer and viral infection. So, a scientific validation to characterize constituents in the alternative medicines and therapeutic testing is warranted using modern instrumentation.MethodsIn the present study, an old herbomineral formulation, KanthaRasavillai [KRV], was characterized using UV–vis spectrometry, FT-IR, XRD, SEM, and TEM study. Also, In vitro andin vivostudies were done to evaluate their antiviral and anticancer activity. FT-IR and XRD studies revealed a cocktail of nanoparticles of mercury, magnetic oxide, cinnabar, and arsenic.Results.Based on SEM, TEM, and XRD report, KRV contains nanoparticles in the size range of 9.1 nm to 25.0 nm. FT-IR analysis exposed the presence of several anti-cancerous bioactive compounds.Furtherin vitrotesting against HCV virus proved KRV to inhibit HCV virus a close relative to SARS-CoV-2. MTT assay confirmed the anticancer effect of KRV against Huh-7 and MCF-7 cell lines.ConclusionThe anticancer and antiviral properties in the ancient herbomineral drug with a cocktail of metal nanoparticles acknowledge the traditional medical practice as a pioneering approach for present-day ailments. However, the study concludes that the use of KRV depends on safety dosage and genuine preparation as described by ancient saints.
关键词：Herbomineral;Kantha Rasavillai;Nanoparticles;Antiviral and anticancer