文章基本信息

标题：EFFECTS OF ELLAGIC ACID ONLEVELS OF SIALIC ACID AND CARDIAC MARKERS IN RATS WITH MYOCARDIAL INFARCTION
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作者：Ergin Taskin ; Yeter Deger
期刊名称：Fresenius Environmental Bulletin
印刷版ISSN：1018-4619
出版年度：2021
卷号：30
期号：7
页码：9011-9017
语种：English
出版社：PSP Publishing
摘要：It has been shown that ellagic acid (EA)nor-malizes the activities of antioxidative enzymes, de-creases the levels of inflammatory cytokines, and modulate the expression of apoptotic protein. The aim of this study was to evaluate the effect ofEA on levels of sialic acid(SA)and cardiac markers in iso-proterenol (ISO)-induced MI in rats. 32 female Wistar-albino rats were divided into 4 groups each containing8 rats:groupI(healthy con-trol group),group II(ISO group),group III(EA +ISO group),and group IV(EA group). Serum total SA (TSA), lipit-bound SA(LSA), and creatine kinase-myocardial band(CK-MB)lev-els were lower in EA+ISO group than in ISO group. Remarkably,serum LSA levels showed a significant positively correlation with all cardiac markers(CK-MB, cardiac troponin I(cTn),and lactate dehydro-genase(LDH). In the histopathological examina-tion, there was less degeneration in myocardial tissue of the rat in EA+ISO group than in those of ISO group. This study shows that EA has a protective ef-fect in ISO-induced MI in rats. Also, it is seen that serum levels of SA, especially LSA, can be used as a cardiac damage marker.
关键词：Ellagic acid;myocardial infarction;sialic acids;Isopro-terenol