文章基本信息

标题：Biosynthesis, characterization and antiproliferative activity of green synthesized gold nanoparticles using Lantadene A extracted from Lantana camara
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作者：Dawood Ali Salim Dawood ; Dawood Ali Salim Dawood ; Lee Suan Chua 等
期刊名称：Karbala International Journal of Modern Science
印刷版ISSN：2405-609X
电子版ISSN：2405-609X
出版年度：2021
卷号：7
期号：4
页码：313-326
DOI：10.33640/2405-609X.3158
语种：English
出版社：Elsevier
摘要：This study was focused on the biosynthesis of gold nanoparticles loaded with lantadene A (LA-AuNPs) from Lantana camara extract and the antiproliferative effects on prostate cancer cells (LNCaP). The synthesized LA-AuNPs had smooth surface, and nearly spherical in shape (67.94 nm) with the zeta potential (-30.11±0.83 mV). LAAuNPs showed a dose dependent cytotoxic activity with IC50, 126.82 µg/ mL against LNCaP, but non-cytotoxic to normal prostate cells. The intrinsic pathway of apoptosis was caused by the increase of caspases-3/7 and -9 activity and cell cycle arrest at the G0/G1 phase. Therefore, LA-AuNPs could be a potent lead to inhibit LNCaP.
关键词：gold nanoparticles;green synthesis;lantadene A;anti-cancer