文章基本信息

标题：Analytical method development and validation for the quantification of metaldehyde in soil
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作者：Nathan Keighley ; Carmel Ramwell ; David Werner 等
期刊名称：MethodsX
印刷版ISSN：2215-0161
电子版ISSN：2215-0161
出版年度：2021
卷号：8
页码：1-6
DOI：10.1016/j.mex.2021.101482
语种：English
出版社：Elsevier
摘要：AbstractPreviously published methods for the analysis of metaldehyde were adapted for its reliable quantification in soil extracts. Varied methanol-water extraction solvents were trialed, but the use of pure methanol proved to be the most reliable approach for the scaled down methodology. Analysis of metaldehyde was done using LC-MS. Initially the method had problems with matrix suppression of the signal. The method was therefore further developed to overcome this challenge to avoid the costs and time demands of laborious clean-up protocols. This modification to the method involved use of the BEH Phenyl column instead of the C18column initially used, and optimization of the gradient flow of the mobile phase. The optimized LC-MS method was validated and used for further research applications. In brief,•We investigated the recovery of metaldehyde from spiked soil samples.•The optimized LC-MS method achieved acceptable metaldehyde recoveries (100–132%, 109% on average) for a range of soil types.•The optimized method was suitable for high through-put analyzes.Graphical abstractDisplay Omitted
关键词：Soil extraction;Matrix suppression;Optimized recoveries