文章基本信息

标题：Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations
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作者：Evgenios Agathokleous ; Michael N Moore ; Edward J Calabrese 等
期刊名称：MethodsX
印刷版ISSN：2215-0161
电子版ISSN：2215-0161
出版年度：2021
卷号：8
页码：1-8
DOI：10.1016/j.mex.2021.101568
语种：English
出版社：Elsevier
摘要：AbstractThe number of studies reporting hormetic responses is rapidly increasing, and quantitative evaluations are needed to improve the understanding of hormetic dose responses. However, there is no standardized methodology to estimate the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships developed using data mined from the published literature. Here, we propose a protocol that can be followed to estimate NOAEL, a process that is illustrated using a specific example. This protocol can be used for maintaining a mutual language (since NOAEL can be defined in different ways), permitting comparisons among different studies, and facilitating cumulative science.Graphical abstractDisplay Omitted
关键词：Contaminant effect;Exposure-response relationship;Hormesis;Low-dose biological effects;Organismal response, Oxidative stress;Pollution effects;Susceptibility;Tolerance;Toxicological testing