文章基本信息

标题：Risk of Hip Fractures in Men with Alpha-Blockers: A Nationwide Study Base on Claim Registry
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作者：Seo, Gi-Hyeon ; Lee, Young-Kyun ; Ha, Yong-Chan 等
期刊名称：Journal of Bone Metabolism
印刷版ISSN：2287-6375
出版年度：2015
卷号：22
期号：1
页码：29-32
DOI：10.11005/jbm.2015.22.1.29
语种：English
出版社：The Korean Society for Bone and Mineral Research
摘要：Background
Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database.
Methods
We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR).
Results
Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker.
Conclusions
Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
关键词：Alpha-blocker; Hip fracture; Registries