首页    期刊浏览 2024年12月05日 星期四
登录注册

文章基本信息

  • 标题:An Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults
  • 本地全文:下载
  • 作者:Hiroyuki Hoshiko ; Gertrude G. Zeinstra ; Kaatje Lenaerts
  • 期刊名称:Healthcare
  • 电子版ISSN:2227-9032
  • 出版年度:2021
  • 卷号:9
  • 期号:11
  • DOI:10.3390/healthcare9111583
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:We explored whether metabolic health is linked to intestinal permeability, using a multi-sugar (MS) permeability test, and whether intestinal permeability is correlated with the leaky gut-related markers (LGM) zonulin, LBP, and sCD14. Metabolically healthy ( n = 15) and unhealthy subjects ( n = 15) were recruited based on waist circumference, fasting glucose, and high-density lipoprotein cholesterol levels. Participants underwent an MS permeability test that assessed site-specific permeabilities of the gastroduodenum and small and large intestines. The test was performed with/without an acetylsalicylic acid challenge to measure and correlate the gut permeability, LGM, and metabolic health. At baseline, metabolic health showed no correlation with gut permeability. Significant correlations were found between the metabolic health parameters and LGM. In the acetylsalicylic acid challenged MS permeability test, low-density lipoprotein cholesterol was correlated with the sucralose/erythritol ratio, reflecting the whole intestinal permeability. Correlations between most metabolic health parameters and LGM during the acetylsalicylic acid challenge were less pronounced than at baseline. In both MS permeability tests, no significant correlations were found between LGM (plasma and serum) and gut permeability. Thus, correlations between LGM and metabolic health might not be linked with paracellular gut permeability. Transcellular translocation and/or lipoprotein-related transportation is a more likely mechanism underlying the association between LGM and metabolic health.
  • 关键词:metabolic; intestinal permeability; multi-sugar; leaky gut
国家哲学社会科学文献中心版权所有