文章基本信息

标题：ZnO Tips Dotted with Au Nanoparticles—Advanced SERS Determination of Trace Nicotine
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作者：Jiaying Cao ; Yan Zhai ; Wanxin Tang 等
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2021
卷号：11
期号：11
DOI：10.3390/bios11110465
语种：English
出版社：MDPI Publishing
摘要：Long-term exposure to nicotine causes a variety of human diseases, such as lung damage/adenocarcinoma, nausea and vomiting, headache, incontinence and heart failure. In this work, as a surface-enhanced Raman scattering (SERS) substrate, zinc oxide (ZnO) tips decorated with gold nanoparticles (AuNPs) are fabricated and designated as ZnO/Au. Taking advantage of the synergistic effect of a ZnO semiconductor with morphology of tips and AuNPs, the ZnO/Au-based SERS assay for nicotine demonstrates high sensitivity and the limit of detection 8.9 × 10 −12 mol/L is reached, as well as the corresponding linear dynamic detection range of 10 −10–10 −6 mol/L. Additionally, the signal reproducibility offered by the SERS substrate could realize the reliable determination of trace nicotine in saliva.
关键词：SERS; ZnO tips; nicotine; AuNPs