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标题：Prenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study
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作者：Michiel A. van den Dries ; Alexander P. Keil ; Henning Tiemeier 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2021
卷号：129
期号：11
DOI：10.1289/EHP9178
语种：English
出版社：OCR Subscription Services Inc
摘要：Background: Prenatal exposure to mixtures of nonpersistent chemicals is universal. Most studies examining these chemicals in association with fetal growth have been restricted to single exposure models, ignoring their potentially cumulative impact. Objective: We aimed to assess the association between prenatal exposure to a mixture of phthalates, bisphenols, and organophosphate (OP) pesticides and fetal measures of head circumference, femur length, and weight. Methods: Within the Generation R Study, a population-based cohort in Netherlands ( n = 776 ), urinary concentrations of 11 phthalate metabolites, 3 bisphenols, and 5 dialkylphosphate (DAP) metabolites were measured at < 18 , 18–25, and > 25 weeks of gestation and averaged. Ultrasound measures of head circumference, femur length, and estimated fetal weight (EFW) were taken at 18–25 and > 25 weeks of gestation, and measurements of head circumference, length, and weight were performed at delivery. We estimated the difference in each fetal measurement per quartile increase in all exposures within the mixture with quantile g-computation. Results: The average EFW at 18–25 wk and > 25 wk was 369 and 1,626 g , respectively, and the average birth weight was 3,451 g . Higher exposure was associated with smaller fetal and newborn growth parameters in a nonlinear fashion. At 18–25 wk, fetuses in the second, third, and fourth quartiles of exposure (Q2–Q4) had 26 g [ 95 % confidence intervals ( CI ) : − 38 , − 13