To analyze the clinical features and determine the factors that affect glaucomatous change of patients with Posner-Schlossman syndrome (PSS).

A retrospective analysis of 51 eyes of 51 patients diagnosed with PSS was performed. We analyzed the factors including age of first attack, highest intraocular pressure (IOP), duration of the disease, number of the attacks and interval between attacks among the patients who developed glaucoma and those who did not and compared the 2 groups.

The age of first attack was 34.73 ± 10.77 years, and highest IOP was 47.75 ± 9.43 mm Hg. Duration of the disease was 62.06 ± 69.84 months, number of the attacks was 6.20 ± 7.73 times, and interval between attacks was 12.65 ± 8.95 months. Of 51 eyes of 51 patients, 12 eyes (23.5%) of 12 patients showed significant glaucomatous change. In the glaucoma group, highest IOP was 52.81 ± 7.87 mm Hg, number of attacks was 11.91 ± 10.63 times, and interval between attacks was 8.07 ± 3.97 months. In the non-glaucomatous group highest IOP was 46.19 ± 9.14 mm Hg, number of attacks was 4.59 ± 5.94 times, and interval between attacks was 14.59 ± 9.79 months, respectively. Highest IOP was significantly greater, number of attacks was higher, and interval was shorter with statistical significance in the glaucoma group ( p = 0.025, p = 0.001, p = 0.028).

A significant number of patients with PSS tend to show glaucomatous change over time. Patients with high IOP during attacks and those having frequent attacks with short intervals should be closely monitored and evaluation for glaucomatous damage is recommended.